Judith Peterschmitt , Leorah Ross , Nathan Thibault , and Sandrine Turpault Jul 6, 2006 · Group 2 was administered ketoconazole (400 mg day −1) on days 1–20 plus a single 0
Here, AADAC catalyzes the formation of M1, which is further metabolized by flavin-containing monooxygenase 3 (FMO3) to M2
M9 (Ketoconazole) Only 2-4% of the ketoconazole dose is eliminated unchanged in the urine
In typical Phase 1 ketoconazole drug interaction studies, the duration of exposure to ketoconazole is limited, and study participants are healthy volunteers without liver disease or other predisposing
Ketoconazole is 83
Drug metabolism mainly occurs in the liver, where 2 types of reactions occur
More attentions should be
Ketoconazole works as an antifungal agent by inhibiting the cytochrome P450 14α-demethylase enzyme
Ketoconazole is an imidazole fungicidal agent with a very broad spectrum of activity against many fungal species that is used for treatment of superficial and systemic fungal infections
Norethindrone
For doses below 400 mg, pronounced drug–food
Ketoconazole is an antifungal agent, which belongs to the group of azoles (imidazole) [ 1 ], was discovered in 1976 by Janssen Pharmaceutica, and was first introduced in 1977
MDCA employs permeabilized cofactor-supplemented cryopreserved human hepatocytes (MetMax Human Hepatocytes, MMHH), as an
Ketoconazole cellular biology continues to be actively studied [4]
CYP3A4 is one of the most important and most abundant drug-metabolizing CYP
The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies and toxic compounds in the environment
Orally administered tioconazole is extensively metabolized
Drug metabolism is a process that facilitates drug clearance by (1) increasing solubility, or (2) being responsible for converting prodrugs to their active drug form (along with the formation of potentially toxic metabolites)
The pharmacology, microbiology, pharmacokinetics, clinical use, adverse effects, dosage and administration, and drug interactions of ketoconazole are reviewed
Orexin antagonism has been extensively studied in the past decade as an alternative mechanism for the treatment of insomnia [1, 2]
On day 4, isavuconazole was administered immediately after ketoconazole
Metabolism of phenytoin by phase 1 cytochrome P450 (CYP) and phase 2 uridine diphosphate-glucuronosyltransferase (UGT)
Introduction
Ketoconazole is a widely prescribed antifungal drug, which has also been investigated as an anticancer therapy in both clinical and pre-clinical settings
Inhibitors of CYP3A4/5 (gestodene and ketoconazole) and
the results observed are consistent with those expected from CYP3A inhibition of venetoclax and M27 metabolism and M27